9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,3-去)(1,4)苯并恶嗪)-6'-羧酸

9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...基本信息

中文全称

9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,3-去)(1,4)苯并恶嗪)-6'-羧酸

中文别名

英文名称

9'-fluoro-10'-(4-methyl-1-piperazinyl)-7'-oxospiro<cyclopropane-1,3'(2'H)-<7H>pyrido<1,2,3-de><1,4>benzoxazine>-6'-carboxylic acid monohydrochloride

英文别名

9'-fluoro-10'-(4-methyl-1-piperazinyl)-7'-oxospiro[cyclopropane-1,3'(2'H)-[7H]pyrido(1,2,3-de)[1,4]benzoxazine]-6'-carboxylic acid monohydrochloride;9'-fluoro-10'-(4-methylpiperazin-1-yl)-7'-oxo-7'h-spiro[cyclopropane-1,3'-[1,4]oxazino[2,3,4-ij]quinoline]-6'-carboxylic acid;9-Fpobc;Spiro[cyclopropane-1,3'(2'H)-[7H]pyrido[1,2,3-de][1,4]benzoxazine]-6'-carboxylicacid,9'-fluoro-10'-(4-methyl-1-piperazinyl)-7'-oxo;

PSA

75.01000

LogP

1.47500
9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...物化性质

折射率

1.705

闪点

319.3ºC

蒸汽压

1.85E-15mmHg at 25°C

密度

1.54g/cm3

沸点

604.4ºC at 760mmHg
9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...图谱

核磁图谱

13C NMR : Predict

1H NMR : Predict
9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...合成路线

1.合成路线

113211-51-1

113211-53-3

参考文献

Wentland; Perni; Dorff; Rake Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1694 - 1697

2.合成路线

114636-48-5

113211-53-3

参考文献

Wentland; Perni; Dorff; Rake Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1694 - 1697

3.合成路线

94695-50-8

113211-53-3

参考文献

Wentland; Perni; Dorff; Rake Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1694 - 1697
9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...上下游产品

上游产品

94714-58-6

113211-51-1

94695-50-8
左氧氟单酯

109-01-3
N-甲基哌嗪

下游产品

113211-53-3
9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,3-去)(1,4)苯并恶嗪)-6'-羧酸

上游百科 N-甲基哌嗪左氧氟单酯 ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

113211-53-3

9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...基本信息

9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...物化性质

9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...图谱

9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...合成路线

1.合成路线

113211-51-1

113211-53-3

2.合成路线

114636-48-5

113211-53-3

3.合成路线

94695-50-8

113211-53-3

9'-氟-10'-(4-甲基-1-哌嗪基)-7'-氧代螺(环丙烷-1,3'(2'H)-(7H)吡啶并(1,2,...上下游产品

上游产品

下游产品

上游百科