2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late

2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late基本信息

中文全称

中文别名

英文名称

2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late

英文别名

(3-endo)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;3-exo-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester;3a-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid t-butyl ester;(1R,3S,5S)-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester;3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester;tert-butyl exo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;Boc-pseudotropine;(1R,3R,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;(cis)-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester;

PSA

49.77000

LogP

1.84710
2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late图谱

核磁图谱

13C NMR : Predict

1H NMR : Predict
2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late合成路线

1.合成路线

185099-67-6

94%

478837-18-2

参考文献

EXELIXIS, INC.; RICE, Kenneth Patent: WO2012/71509 A2, 2012 ; Location in patent: Page/Page column 166 ; WO 2012/071509 A2

2.合成路线

7432-11-3

24424-99-5

478837-18-2

参考文献

Skjaerbaek, Niels; Koch, Kristian Norup; Mikael Friberg, Bo Lennart; Tolf, Bo-Ragnar Patent: US2005/209226 A1, 2005 ; US 20050209226 A1
2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late上下游产品

上游产品

185099-67-6
N-叔丁氧羰基-去甲托品酮

7432-11-3

478837-18-2

24424-99-5
二碳酸二叔丁酯

下游产品

863249-39-2

478837-18-2

上游百科 (1S,5R)-8-azabicyclo[3.2.1]octan-3-ol 二碳酸二叔丁酯 N-叔丁氧羰基-去甲托品酮

478837-18-2

2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late基本信息

2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late图谱

2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late合成路线

1.合成路线

185099-67-6

478837-18-2

2.合成路线

7432-11-3

24424-99-5

478837-18-2

2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late上下游产品

上游产品

下游产品

上游百科