2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphenyl)-4-methyl-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl] -1-phenylethyl}carbamate

2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...基本信息

中文全称

中文别名

英文名称

2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphenyl)-4-methyl-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl] -1-phenylethyl}carbamate

英文别名

3-[(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2,6-difluorobenzyl]-6-methyl-pyrimidine-2,4(1H,3H)-dione;3-[2(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2,6-difluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione;3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2,6-difluorobenzyl]-6-methyl-pyrimidine-2,4-(1H,3H)-dione;

PSA

95.05000

LogP

5.93000
2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...物化性质

折射率

1.572

密度

1.284g/cm3
2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...图谱

核磁图谱

1H NMR : Predict

13C NMR : Predict
2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...合成路线

1.合成路线

352290-60-9

24424-99-5

99%

830346-53-7

参考文献

NEUROCRINE BIOSCIENCES, INC. Patent: WO2005/7165 A1, 2005 ; Location in patent: Page 53 ; WO 2005/007165 A1

2.合成路线

352303-66-3

830346-53-7

参考文献

Tucci, Fabio C.; Zhu, Yun-Fei; Struthers, R. Scott; Guo, Zhiqiang; Gross, Timothy D.; Rowbottom, Martin W.; Acevedo, Oscar; Gao, Yinghong; Saunders, John; Xie, Qiu; Reinhart, Greg J.; Liu, Xin-Jun; Ling, Nicholas; Bonneville, Anne K. L.; Chen, Takung; Bozigrian, Haig; Chen, Chen Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 1169 - 1178

3.合成路线

67341-01-9

830346-53-7

参考文献

Tucci, Fabio C.; Zhu, Yun-Fei; Struthers, R. Scott; Guo, Zhiqiang; Gross, Timothy D.; Rowbottom, Martin W.; Acevedo, Oscar; Gao, Yinghong; Saunders, John; Xie, Qiu; Reinhart, Greg J.; Liu, Xin-Jun; Ling, Nicholas; Bonneville, Anne K. L.; Chen, Takung; Bozigrian, Haig; Chen, Chen Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 1169 - 1178
2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...上下游产品

上游产品

352303-66-3
5-溴-1-(2,6-二氟苄基)-6-甲基-2,4(1H,3H)-嘧啶二酮

352303-69-6
2-甲基-2-丙基{(1R)-2-[5-溴-3-(2,6-二氟苄基)-4-甲基-2,6-二氧代-3,6-二氢-1(2H)-嘧啶基]-1-苯基乙基}氨基甲酸酯

352303-67-4
2-氟-3-甲氧基苯硼酸

352290-60-9
NBI 42902

下游产品

352290-60-9
NBI 42902

830346-53-7

上游百科 2-氟-3-甲氧基苯硼酸二碳酸二叔丁酯 N-Boc-DL-苯甘氨醇 NBI 42902
下游百科 NBI 42902

830346-53-7

2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...基本信息

2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...物化性质

2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...图谱

2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...合成路线

1.合成路线

352290-60-9

24424-99-5

830346-53-7

2.合成路线

352303-66-3

830346-53-7

3.合成路线

67341-01-9

830346-53-7

2-Methyl-2-propanyl {(1R)-2-[3-(2,6-difluorobenzyl)-5-(2-fluoro-3 -methoxyphen...上下游产品

上游产品

下游产品

上游百科

下游百科