N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺

N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺基本信息

中文全称

N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺

中文别名

英文名称

N-(3-chloro-4-fluorophenyl)-7-(3-morpholin-4-ylpropoxy)-6-nitroquinazolin-4-amine

英文别名

(3-chloro-4-fluorophenyl)-[7-(3-morpholino-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine;(3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazoline-4-yl]-amine;I14-9229;(3-CHLORO-4-FLOUROPHENYL)-[7-(3-MORPHOLIN-4-YL-PROPOXY)-6-NITRO-QUINAZOLINE-4YL]-AMINE;N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine;4-[N-(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline;(3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine;

PSA

105.33000

LogP

4.70930
N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺物化性质

折射率

1.649

闪点

339.085ºC

蒸汽压

0mmHg at 25°C

密度

1.418g/cm3

沸点

637.065ºC at 760 mmHg
N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺图谱

核磁图谱

13C NMR : Predict

1H NMR : Predict
N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺合成路线

1.合成路线

4441-30-9

367-21-5

162012-69-3

94%

267243-64-1

参考文献

Barth, Hubert; Bridges, Alexander James; Heemstra, Ronald J.; Horne, Nicole Marcia; Hughes, Robert Craig; Jacks, Thomas Elliott; McNamara, Dennis Joseph; Schneider, Simon; Steiner, Klaus; Toogood, Peter Laurence; Winters, Roy Thomas Patent: US2004/158065 A1, 2004 ; Location in patent: Page 20 ;

2.合成路线

4441-30-9

162012-67-1

65%

267243-64-1

参考文献

Hur, Wooyoung; Velentza, Anastasia; Kim, Sungjoon; Flatauer, Laura; Jiang, Xinnong; Valente, David; Mason, Daniel E.; Suzuki, Melissa; Larson, Brad; Zhang, Jianming; Zagorska, Anna; DiDonato, Michael; Nagle, Advait; Warmuth, Markus; Balk, Steven P.; Peters, Eric C.; Gray, Nathanael S. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 22 p. 5916 - 5919

3.合成路线

162012-70-6

267243-64-1

参考文献

Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A. Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397
N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺上下游产品

上游产品

10519-96-7
三甲基硅醇钾

367-21-5
3-氯-4-氟苯胺

4441-30-9
4-(3-羟丙基)吗啉

865-47-4
叔丁醇钾

下游产品

267243-68-5
N4-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)喹唑啉-4,6-二胺

267243-64-1
N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺

上游百科 叔丁醇钾三甲基硅醇钾 4-(3-羟丙基)吗啉 3-氯-4-氟苯胺 7-氟-6-硝基-4-羟基喹唑啉 4-氯-7-氟-6-硝基喹唑啉 N-(3-氯-4-氟苯基)-7-氟-6-硝基-4-喹唑啉胺 N4-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)喹唑啉-4,6-二胺
下游百科 N4-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)喹唑啉-4,6-二胺

267243-64-1

N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺基本信息

N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺物化性质

N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺图谱

N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺合成路线

1.合成路线

4441-30-9

367-21-5

162012-69-3

267243-64-1

2.合成路线

4441-30-9

162012-67-1

267243-64-1

3.合成路线

162012-70-6

267243-64-1

N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺上下游产品

上游产品

下游产品

上游百科

下游百科