Vemakalant

Vemakalant基本信息

中文全称

Vemakalant

中文别名

英文名称

(3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol

英文别名

UNII-9G468C8B13;(3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol;Vernakalant [INN:BAN];(1R,2R)-2-[(3R)-hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)cyclohexane;(1R-{2R-[2-(3,4-dimethoxyphenyl)-ethoxy]-cyclohex-2-yl})-pyrrolidin-3R-ol;1R-(2R-(2-(3,4-dimethoxy-phenyl)-ethoxy)-cyclohexyl)-pyrrolidin-3R-ol;(3R)-1-{(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl}pyrrolidinol;Vernakalant;Vernakalant [INN];(3R)-1-{(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl}pyrrolidin-3-ol;RSD 1235;

PSA

51.16000

LogP

2.57860
Vemakalant图谱

核磁图谱

13C NMR : Predict

1H NMR : Predict
Vemakalant合成路线

1.合成路线

906802-36-6

77%

794466-70-9

参考文献

CARDIOME PHARMA CORP. Patent: WO2006/88525 A1, 2006 ; Location in patent: Page/Page column 118; 127-128 ;

2.合成路线

795282-03-0

794466-70-9

参考文献

CARDIOME PHARMA CORP.; ROTH, Carol, J. Patent: WO2006/138673 A2, 2006 ; Location in patent: Page/Page column 49; 74-75 ;

3.合成路线

1360617-31-7

794466-70-9

参考文献

Limanto, John; Ashley, Eric R.; Yin, Jingjun; Beutner, Gregory L.; Grau, Brendan T.; Kassim, Amude M.; Kim, Mary M.; Klapars, Artis; Liu, Zhijian; Strotman, Hallena R.; Truppo, Matthew D. Organic Letters, 2014 , vol. 16, # 10 p. 2716 - 2719
Vemakalant上下游产品

上游产品

906802-36-6

795282-03-0

7417-21-2
3,4-二甲氧基苯乙醇

19398-47-1
1,4-二溴-2-丁醇

下游产品

794466-70-9
Vemakalant

上游百科 2-氯环己酮 3,4-二甲氧基苯乙醇 1,4-二溴-2-丁醇 (3R)-1-(2-(3,4-dimethoxyphenethoxy)cyclohexyl)-2,5-dioxopyrrolidin-3-yl acetate

794466-70-9

Vemakalant基本信息

Vemakalant图谱

Vemakalant合成路线

1.合成路线

906802-36-6

794466-70-9

2.合成路线

795282-03-0

794466-70-9

3.合成路线

1360617-31-7

794466-70-9

Vemakalant上下游产品

上游产品

下游产品

上游百科