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4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基]-四氢吡喃-2-酮
CAS号：
79902-31-1
分子式：C25H42O4Si
百科
供应商
4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基...基本信息
中文全称
4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基]-四氢吡喃-2-酮
中文别名
英文名称
(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-[tert-butyl(dimethyl)silyl]oxyoxan-2-one
英文别名
1,7-Dioxaspiro[4.4]nonane-2,6-dione,8-(1,2-dihydroxyethyl)-9-hydroxy-4-(p-hydroxyphenyl);6(R)-[2-[8(S)-hydroxy-2(S);Leucodrin;(4R,6R)-6-[2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthyl)ethyl]-4-[(tert-butyldimethylsilyl)oxy]-3,4,5,6-tetrahydro-2H-pyran-2-one;(4R,6R)-4-(tert-butyldimethylsilyloxy)-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one;6(R)-[2-[8(S)-Hydroxy-2(S),6(R)-dimethyl-1,2,6,7,8,8a-(R)-hexahydronaphthyl-1(S)]ethyl]-4(R)-(tert-butyldimethylsilyloxy)-3,4,5,6-tetrahydro-2H-pyran-2-one;6(R)-[2-(8(S)-hydroxy-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydronaphth-1(S)-yl)-ethyl]-4(R)-(dimethyl-tert-butylsilyl-oxy)-3,4,5,6-tetrahydro-2H-pyran-2-one;6(R)-[2-[8'(S)-hydroxy-2'(S),6'(R)-dimethyl-1',2',6',7',8',8a'(R)-hexahydronaphthalene-1'(S)-yl]-ethyl]-4(R)-(dimethyl-tert-butylsilyloxy)-3,4,5,6-tetrahydro-2H-pyran-2-one;6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)]ethyl]-4(R)-(tert-butyldimethylsilyloxy)-3,4,5,6-tetrahydro-2H-pyran-2-one;(4R,5S,8R)-8r-((S)-1,2-dihydroxy-ethyl)-9t-hydroxy-4-(4-hydroxy-phenyl)-1,7-dioxa-spiro[4.4]nonane-2,6-dione;tert-butyldimethylsiloxymonacolin J;(4R,5S,8R)-8r-((S)-1,2-Dihydroxy-aethyl)-9t-hydroxy-4-(4-hydroxy-phenyl)-1,7-dioxa-spiro[4.4]nonan-2,6-dion;
PSA
55.76000
LogP
5.62800
4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基...物化性质
折射率
1.514
闪点
280.622ºC
密度
1.047g/cm3
沸点
540.396ºC at 760 mmHg
4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基...图谱
核磁图谱
13C NMR : Predict
1H NMR : Predict
4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基...合成路线
1.合成路线
151006-15-4
18162-48-6
99%
79902-31-1
参考文献
CJ CORP. Patent: WO2004/96789 A1, 2004 ; Location in patent: Page 10-11; 8 ;
2.合成路线
75-07-0
143746-93-4
79902-31-1
136432-18-3
136521-50-1
参考文献
Hartman; Halczenko; Duggan; Imagire; Smith; Pitzenberger; Fitzpatrick; Alberts; Bostedor; Chao; Germershausen; Gilfillan; Hunt Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3813 - 3821
3.合成路线
132748-10-8
79902-31-1
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 1 p. 50 - 59
4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基...上下游产品
上游产品
143746-93-4
75-07-0
乙醛
84131-91-9
(S)-(+)-2-甲基丁酸酐
151006-15-4
下游产品
136521-50-1
75330-75-5
洛伐他汀
79902-31-1
4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基]-四氢吡喃-2-酮
136432-18-3
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4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基]-四氢吡喃-2-酮
上游百科
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叔丁基二甲基氯硅烷
洛伐他汀
下游百科
洛伐他汀