4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔丁酯

4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...基本信息

中文全称

4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔丁酯

中文别名

1-(1-叔丁氧羰基哌啶-4-基)吡唑-4-硼酸频那醇酯;1-(N-Boc-哌啶4基)吡唑-4-硼酸频哪醇酯;

英文名称

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

英文别名

1-(4-N-Boc-piperidine)pyrazole-4-boronic acid pinacol ester;1-Piperidinecarboxylic acid,4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl]-,1;tert-butyl 4-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H;4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl)piperidine-1-carb;1-(1-Boc-4-piperidyl)pyrazole-4-boronic acid pinacol ester;4-[4-(4,4,5,5--1,3,2--2-)-1H--1-]-1- ();tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl) piperidine-1-carboxylate;tert-Butyl 4-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxyla;4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester;4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-piperidin-1-carboxylic acid tert-butyl ester;5-BroMo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylaMine;4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;4-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)PIPERIDINE-1-CARBOXYLATE;

PSA

65.82000

LogP

2.69220
4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...物化性质

折射率

1.539

闪点

251.838ºC

密度

1.14 g/cm3

沸点

492.803ºC at 760 mmHg
4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...安全信息

海关编码

2934999090
4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...图谱

核磁图谱

1H NMR : Predict

13C NMR : Predict
4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...合成路线

1.合成路线

877399-73-0

1195-66-0

82%

877399-74-1

参考文献

De Koning, Pieter D.; McAndrew, Douglas; Moore, Robert; Moses, Ian B.; Boyles, David C.; Kissick, Kyle; Stanchina, Corey L.; Cuthbertson, Timothy; Kamatani, Asayuki; Rahman, Leera; Rodriguez, Rick; Urbina, Armando; Sandovalnee Accacia, Alison; Rose, Peter R. Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1018 - 1026

2.合成路线

877399-73-0

73183-34-3

81%

877399-74-1

参考文献

CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Xiaobo; ZHOU, Shiqing Patent: WO2014/89280 A1, 2014 ; Location in patent: Page/Page column 50 ;

3.合成路线

877399-50-3

1195-66-0

80%

877399-74-1

参考文献

Qian, Jian-Qiang; Yan, Pu-Cha; Che, Da-Qing; Zhou, Qi-Lin; Li, Yuan-Qiang Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1528 - 1531
4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...海关数据

中国海关编码

2934999090

概述

2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素

品名, 成分含量, 用途
4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...上下游产品

上游产品

877399-73-0
4-(4-碘-1H-吡唑-1-基)-1-哌啶羧酸叔丁酯

1195-66-0
2-甲氧基-4,4,5,5-四甲基-1,3,2-二氧硼戊环

877399-50-3
4-(4-溴吡唑-1-基)哌啶-1-甲酸叔丁酯

877399-74-1
4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔丁酯

下游产品

1175273-62-7
1-(4-哌啶基)-1H-吡唑-4-硼酸频那醇盐酸盐

877399-74-1
4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔丁酯

上游百科 4-羟基哌啶 2-甲氧基-4,4,5,5-四甲基-1,3,2-二氧硼戊环异丙醇频哪醇硼酸酯 4-吡唑硼酸频哪醇酯二碳酸二叔丁酯联硼酸频那醇酯 1-Boc-4-甲烷磺酰氧基哌啶 4-(4-溴吡唑-1-基)哌啶-1-甲酸叔丁酯 4-(4-碘-1H-吡唑-1-基)-1-哌啶羧酸叔丁酯
下游百科 1-(4-哌啶基)-1H-吡唑-4-硼酸频那醇盐酸盐

877399-74-1

4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...基本信息

4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...物化性质

4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...安全信息

4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...图谱

4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...合成路线

1.合成路线

877399-73-0

1195-66-0

877399-74-1

2.合成路线

877399-73-0

73183-34-3

877399-74-1

3.合成路线

877399-50-3

1195-66-0

877399-74-1

4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...海关数据

4-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔...上下游产品

上游产品

下游产品

上游百科

下游百科